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Nitric Oxide, the Signaling Molecule of Life
Perhaps there is no disease that this miracle molecule does not protect against.
Dr. Louis J. Ignarro, a professor at UCLA's School of Medicine, was awarded the Nobel Prize in Physiology or Medicine in 1998 for his discovery of 'nitric oxide'.
Nitric oxide is an essential signaling molecule that plays a crucial role in various biological systems, opening up new possibilities for treating cardiovascular diseases. It has been discovered that nitric oxide is important not only for vascular health but also for the immune system, nervous system, digestive organs, and other diverse biological systems.
Vasodilation & Increased Blood Flow
This refers to the role of relaxing vascular smooth muscles to expand blood vessels and increase blood flow.
Effects
Hypertension
Angina pectoris
Arteriosclerosis
Numbness in hands and feet
Blood Purification
This refers to the role of preventing blood clot formation and strengthening the immune system to help purify the blood.
Effects
Diabetes
Fatigue
Obesity
Fatty liver
New Blood Vessel Formation
This refers to the key role of stimulating vascular endothelial cells to create new blood vessels.
Effects
Dementia prevention
Wound healing
Aging suppression
Immune modulation
Immune Restoration
This refers to the role of modulating immune responses by acting on various cells of the immune system.
Effects
Pathogens
Harmful substances
Viruses
Toxins
Homeostasis Regulation
This refers to the crucial role of regulating various biological processes to maintain homeostasis.
Effects
Body temperature regulation
pH regulation
Water balance
Blood sugar control
Blood pressure regulation
Research on nitric oxide has driven significant advancements in various fields, including biology, medicine, and pharmacology, since the 1980s. Nitric oxide remains a critical subject of study in the life sciences and is expected to contribute to the treatment and prevention of a wide range of diseases in the future.
Discovery of Nitric Oxide's Role as a Signaling Molecule
In the 1980s, research findings were consistently published demonstrating that nitric oxide plays an important role as a biological signaling molecule, leading to its emergence as a new possibility for treating cardiovascular diseases.
Nitric Oxide Named "Molecule of the Year"
Recognizing its importance, the prestigious weekly scientific journal Science (published by the American Association for the Advancement of Science, AAAS) named nitric oxide the "Molecule of the Year" in 1992.
Nobel Prize in Physiology or Medicine
The pioneers of nitric oxide research, Robert Furchgott, Ferid Murad, and Louis Ignarro, were awarded the Nobel Prize in Physiology or Medicine for their contributions in demonstrating the role and influence of nitric oxide as a signaling molecule in the cardiovascular system.
Continued Research and Development
Since the 20th century, nitric oxide has become one of the most studied molecules, with the highest number of published papers. As research revealed its crucial roles not only in vascular health but also in the central nervous system, respiratory system, digestive system, sexual function, and immune system, research into developing related disease treatments has also become highly active.
The leading cause of death globally and the number one burden of disease in Korea is vascular disease. This is primarily because the amount of nitric oxide, a substance that helps blood vessels relax, decreases as we age.
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